|The plane caught alight as it crashed|
The Cessna 310 aircraft burst in to flames on Interstate 405, just short of a runway at John Wayne Airport in Costa Mesa around 9:30am on Friday.
Orange County Fire Captain Larry Kurtz said two people, a man and a woman in their 50s and 60s, were aboard the plane.
They were pulled out of the burning wreckage before being taken to a local hospital with injuries that are not believed to be life-threatening.
The aircraft clipped a car as it came crashing down in a fireball but the driver escaped with a bruised elbow.
Ian Gregor, a spokesman for the Federal Aviation Administration, said the crash happened under "unknown circumstances" and the pilot declared an emergency shortly after taking off from the airport.
The airfield was closed to arrivals after the crash.
Video showed long tailbacks of traffic along the interstate as fire crews worked to extinguish the flames.
Photos posted on social media showed flames shooting out of the front of the aircraft and smoke surrounding the plane.